FIELD: organic chemistry. SUBSTANCE: invention relates to quinazoline compounds of the formula (I) 
where R1 - lower alkyl or amino-group; R2 - hydrogen atom, lower alkyl, hydroxy-, lower alkoxy-group; R3 - hydrogen atom; Z - oxygen atom; R4 is O, S, CH2, C=O, CHOH, OH-, C(Ph)-; R5 - a residue of the formula indicated in p. 1 of the claim, or their pharmaceutically acceptable salts that show an antiproliferative activity, for example, an antitumor activity. EFFECT: antitumor activity of compounds. 19 cl, 2 tbl
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