DERIVATIVES OF NAPHTHALENE, PHARMACEUTICAL COMPOSITION Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel derivatives of naphthalene of the general formula (I) where R¹ is nonprotected carboxyl group or protected carboxyl group; R² means hydrogen atom, nonprotected hydroxyl group or protected hydroxyl group; R³ means hydrogen atom, nonprotected hydroxyl group , protected hydroxyl group, lower alkyl or halogen atom; R⁴ means hydrogen or halogen atom; A¹ means lower alkylene; A² means the bond or lower alkylene; R⁵ means the group (a) where R⁶ means mono- (or di- or tri-) aryl (lower)alkyl and Z means N or CH or -A³-Q,(R⁷),(R⁸) where values A³, Q, R⁷ and R⁸ are given in the point 1 of the invention claim. Compounds show pharmacological activity, for example, inhibitory, hypotensive activities and they are agonists of prostaglandins I₂. Invention describes also pharmaceutical compositions based on thereof. EFFECT: new compounds indicated above, valuable properties. 6 cl, 38 ex