FIELD: antibiotics, pharmacy. SUBSTANCE: invention describes new derivatives of rapamycin of the general formula (I) 
where values Y, R1,R4 are given in p. 1 of the invention claim. New compounds show immunosuppressive activity. Invention describes also a pharmaceutical composition based on compounds of the formula (I). EFFECT: new compounds indicated above, valuable properties. 6 cl, 30 ex
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