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2 155 773

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IPC

(21) (22)

Application

97110075/04, 1995-11-14

(24)

Start date

1995-11-14

(22)

Actual filing date

1995-11-14

(45)

Published

2000-09-10

(72)

Inventor

Dzheffri Klejton BejkerViktor Dzhon ChenZhoze Mishel' Ank'EAidas Vladas KriatsiunasBrajan Allen MozerRobert Teodor Shuman

(73)

Holder

Ehli Lilli Ehnd Kompani

METHOD OF SELECTIVE ACYLATION OF PROINSULIN, INSULIN OR INSULIN ANALOG HAVING FREE ε- AND α-AMINOGROUPS Russian patent published in 2000 - IPC

Abstract RU 2155773 C2

FIELD: chemistry of proteins, hormones. SUBSTANCE: invention relates to acylation of proteins and can be used in chemical and medicinal industry. Invention describes a single-step method of selective acylation of ε-aminogroup of proinsulin, insulin or insulin analog in the presence of free α-aminogroup using soluble activated fatty acid ester in polar solvent at pH 9.5-11.5. EFFECT: simplified technology of insulin derivatives producing, high yield of end product. 5 cl, 2 tbl, 9 ex

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RU 2 155 773 C2

Authors

Dzheffri Klejton Bejker

Viktor Dzhon Chen

Zhoze Mishel' Ank'E

Aidas Vladas Kriatsiunas

Brajan Allen Mozer

Robert Teodor Shuman

Dates

2000-09-10—Published

1995-11-14—Filed