FIELD: medicine. SUBSTANCE: monomer insulin analog has A-chain being natural sequence of human insulin A-chain and its B-chain is modified in B28 or B29 or in both positions. The analog is mono-acylated near the N-end of A-chain or B-chain or in lysine. EFFECT: prolonged activity. 12 cl, 1 tbl
Authors
Dates
2000-12-10—Published
1995-11-14—Filed