ORTHO-SUBSTITUTED DERIVATIVES OF BENZOIC ACID, METHOD OF THEIR SYNTHESIS, METHOD OF PREPARING PHARMACEUTICAL COMPOSITION, PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to ortho-substituted derivatives of benzoic acid of the formula (I) where R¹ - alkyl, halogen or XR⁴; R² is SO_n-R⁶ or -SO₂NR⁴R⁵; R³ is CN or halogen; Q is -N=C(NH₂)₂, OA or OH; R⁴,R⁵ are H or C_1-6-alkyl; R⁶ is C_1-6-alkyl; X is O or NR⁵ and n = 2, and their physiologically compatible salts and a pharmaceutical composition based on compounds said shows cardioprotective effect. Compounds can be used for drugs preparing or as intermediate compounds for synthesis of other active substances. EFFECT: improved method of synthesis. 7 cl, 1 tbl, 20 ex