3-INDOLYLPIPERIDINES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to the novel 3-indolylpiperidines of the formula (I) where R¹, R², R³, R⁴ mean H, A, OH, OA, F, Cl, Br, J, CN, CF₃, COOH, CONH₂, CONHA, CONA₂ or COOA; or R¹ and R² and also R³ and R⁴ in common mean methylenedihydroxy-group; R⁵ is H or OH; R⁶ is H or R⁵ and R⁶ in common mean a bond; A means C₁-C₆-alkyl; n is the whole number from 2 to 6, and their physiologically acceptable salts. Compounds of the formula (I) show effect on central nervous system, especially they show serotonin-agonistic or serotonin-antagonistic effect. EFFECT: improved method of synthesis, valuable pharmacological properties. 5 cl, 2 tbl, 12 ex