CONDENSED PYRROLE CARBOXANILIDES, NEW CLASS OF LIGANDS OF CEREBRAL GABA-RECEPTORS Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacology. SUBSTANCE: invention describes the novel derivatives of condensed pyrrole carboxamide of the general formula (I) and their pharmaceutically nontoxic salts where fragment (a) means groups of the formulas (b) and (c) given in the invention description and W means substituted or unsubstituted aryl; X means hydrogen atom, hydroxyl or lower alkyl; T means hydrogen, halogen atom, hydroxyl, amino-group or alkyl; R₃ means hydrogen atom or organic group; R₄ means hydrogen atom or substituted or unsubstituted organic substituent; R₅ and R₆ mean organic and inorganic substituents; n = 1, 2, 3 or 4. These compounds are highly active agonists, antagonists or reverse agonists of cerebral GABA-receptors or prodrugs of agonists, antagonists or reverse agonists of cerebral GABA-receptors. These compounds are useful also in diagnosis and treatment of patients with neurosis, insomnia, epilepsy, overdosing with drugs of benzodiazepine order and for memory improvement. EFFECT: new compounds indicated above, valuable pharmacological properties. 51 cl, 22 dwg, 1 tbl, 8 ex