NEW CONDENSED PYRROLE CARBOXYLIC ACID AMIDES: NOVEL CLASS OF LIGANDS OF BRAIN GABA-RECEPTORS Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacology. SUBSTANCE: invention relates to novel condensed pyrrole carboxylic acid amides of the general formula (I) where G means Q-(C)_k-W-(C)_m-Z where Q means phenyl, 2-, 3-, 4-pyridyl that can be substituted; T means halogen, hydrogen atom, hydroxyl, amino- C₁-C₆-alkoxy-group; W means -O-, -N-, -S-, CR₇R₈ where R₇ and R₈ are similar or distinct and mean H, C₁-C₆-alkyl; X is hydrogen atom; Z means hydroxyl, C₁-C₆-alkoxy-, C₃-C₇-cyclo-alkylalkoxy-group, NH₂ and others, NR₉COR₁₀ where R₉ and R₁₀ are similar or distinct and they mean H, C₁-C₆-alkyl and others, or Z is bound optionally through W to Q forming 1-6-membered ring; k, m, n = 0-3; R₃, R₄, R₅, R₆ are similar or distinct and mean H, C₁-C₆-alkyl, -CO₂R₁₁ where R₁₁ means C₁-C₆-alkyl, C₃-C₇-cycloalkyl, CONR₁₂R₁₃ where R₁₂ and R₁₃ mean H, C₁-C₆-alkyl, C₃-C₇-cycloalkyl. Compound of the formula (I) show selective binding with GABA-receptors that ensures to use their in treatment of patients with fear, sleep disorder and seizures. EFFECT: new compounds indicated above, valuable medicinal and pharmacological properties. 56 cl, 2 tbl, 4 ex