SOME CONDENSED PYRROLECARBOXANILIDES, NEW CLASS OF LIGANDS FOR BRAIN GABA-RECEPTORS Russian patent published in 1999 - IPC

FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to compounds of the formula (I) where fragment (a) means groups of the formulas (b) or (c) and where W means free or substituted phenyl or 6-quinolinyl; y means a group C-R⁴; Z means C(R⁸)(R⁹); R³,R⁴,R⁵,R⁶,R⁸,R⁹ mean hydrogen. These compounds are highly active agonists, antagonists or reverse agonists of the brain GABA-receptors or prodrugs of agonists, antagonists or reverse agonists of the brain GABA-receptors. These compounds can be used for diagnosis and treatment of patients with neurosis, insomnia, epilepsy, at overdosing with drugs of benzodiazepine order and for memory improvement. EFFECT: new compounds indicated above, enhanced effectiveness of compounds. 24 cl, 5 dwg, 1 tbl, 8 ex