PEPTIDE SPECIFICITY OF ANTIBODY TO MYELIN BASIC PROTEIN, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND METHOD OF TREATMENT OF PATIENTS WITH CEREBROSPINAL SCLEROSIS Russian patent published in 2000 - IPC

FIELD: chemistry of peptides, medicine, neurology, pharmacy. SUBSTANCE: invention describes a new peptide or its salt that is able to neutralize or modulate the formation of antibodies raised to against myelin basic protein. Peptide has formula (I): R₁- -Val-His-Phe-Phe-Lys-Asn-Ile-R₂ where R₁ is taken among the group including: Asn-Pro-Val-; Pro-Val-; Val-; Lys-Ser-His- -Gly-Arg-Thr-Gln-Asp-Glu-Asn-Pro-Val-; Thr-Gln-Asp-Glu-Asn-Pro- -Val-; hydrogen atom and hydroxy-group; R₂ is taken among the group including: -Val; -Val-Thr-; -Val-Thr-Pro; -Val-Thr-Pro- -Arg-; hydrogen atom and hydroxy-group under condition that R₁ and R₂ are not hydrogen atom or hydroxyl simultaneously. This peptide has substitutions, additions or deletions. Invention describes also pharmaceutical composition based on compounds of the general formula (I) and method of treatment of patients with cerebrospinal sclerosis. EFFECT: enhanced effectiveness of treatment of patients. 8 cl, 10 dwg, 2 tbl, 2 ex