METHOD FOR DIAGNOSING ATHEROSCLEROGENIC BLOOD VESSEL INJURIES Russian patent published in 2000 - IPC

FIELD: medicine. SUBSTANCE: method involves taking venous blood before removing arterial cord from cubital veins of the extremity under study and contralateral extremity. Heparin concentration, antithrombin III activity, prothrombin time, factor VIII activity, maximum erythrocyte aggregates strength, collagen-induced blood platelets aggregation amplitude, plasminogen activity and activated partial thromboplastin time are determined to calculate A value from formula: A= 11.135ΔHP - 7.939 ΔATIII - 30.130 ΔEDVD + 25.38 ΔPTT + 3.122 ΔV III - 6.932 ΔUd - 5.216 Δ Coll - 9.144 ΔPL - 12.851ΔATPT, where ΔHP is the endogenous heparin concentration increment (%), ΔATIII is the antithrombin III activity increment, ΔEDVD is the endothelium-dependent vasodilation (%), ΔPTT is the prothrombin time increment, ΔVIII is the factor VIII activity increment after applying cuff test (%), Ud is the maximum erythrocyte aggregates strength increment (%), ΔPL is the plasminogen activity increment (%), ΔPL is the plasminogen activity after the cuff test, ΔATPT is the activated partial thromboplastin time duration increment (%). The value of A being greater than 169.883, initial stage of atherosclerogenic blood vessel injury is considered to be the case. The value of A being less than 169.883, marked atherosclerogenic blood vessel injuries are considered to be the case. EFFECT: high accuracy of diagnosis. 2 tbl