METHOD FOR DIAGNOSING THE CASES OF ATHEROSCLEROTIC VASCULAR INJURIES Russian patent published in 2000 - IPC

FIELD: medicine. SUBSTANCE: method involves taking venous blood sample before taking off arterial cord from cubital veins of extremity under study and contralateral one. XIIa-dependent fibrinolysis duration, VIII factor, plasminogen, antithrombin III activity, ADP-induced blood platelets aggregation amplitude are determined. Vascular endothelium reactivity index is calculated using a formula Z= 35.325EDVD-2.901ΔXIIa-3.768ΔVIII+8.022ΔPL-2.76ΔADP- 2.211ΔATIII where EDVD is the value of endothelium-dependent vasodilatation (%), ΔXIIa is the XIIa-dependent fibrinolysis duration increment (%), ΔVIII is the VIII factor activity increment after performing cuff test(%), ΔPL is the plasminogen activity increment after performing cuff test (%), ΔADP is the ADP-induced blood platelets aggregation amplitude increment(%), ΔATIII is the antithrombin III activity increment (%). Z value being greater than 179.027, no atherosclerotic vascular injury is to be diagnosed. The value of Z being less than 179.027, atherosclerotic vascular injury is diagnosed. EFFECT: high informativity and accuracy of diagnosis. 2 tbl