BENZAZEPIN, BENZOXAZEPIN OR BENZOTHIAZEPIN-N-ACETIC ACID, METHOD OF PREPARATION THEREOF, AND DRUG CONTAINED THEREIN Russian patent published in 2000 - IPC

FIELD: chemical industry. SUBSTANCE: described are new benzazepin-, benzoxazepin, benzothiazepin N-acetic acid derivatives of general formula I: wherein R¹ is (lower) alkoxy (lower) alkyl group, lower alkoxy residue of which group is substituted by lower alkoxy group, phenyl (lower) alkyl group; or phenyloxy (lower) alkyl group which is optionally substituted by lower alkyl, lower alkoxy or halogen in phenyl ring, or naphthyl (lower) alkyl group; A is CH₂, O or S; R² is hydrogen or halogen; R³ is hydrogen or halogen; R⁴ is hydrogen or biolabile ester-forming group; R⁵ is hydrogen or biolabile ester - forming group and physiologically tolerable salts of acids of formula I. Said compounds have useful pharmacological properties which are effective with respect to heart and show clearly expressed suppressing effect on neutral endopeptidase, diminish high heart filling pressure that occurs because of heart insufficiency and thus discharge heart and may induce greater liuresis. Also described are method of preparing compounds of formula I and drug that contains said compounds. EFFECT: improved properties of the title compounds. 9 cl, 21 ex, 1 tbl