SOLID BENZAZEPIN COMPOUND SALTS AND THEIR USE IN PREPARATION OF PHARMACEUTICAL COMPOUNDS Russian patent published in 2007 - IPC C07K5/78 A61K38/05 A61P9/00

Abstract RU 2303041 C2

FIELD: pharmaceutical chemistry.

SUBSTANCE: invention relates to compounds of general formula: , wherein R₁ represents phenyl-С₁-С₆-alkyl group or 1-naphthyl-С₁-С₆-alkyl group; R₂ biologically labile ether forming group in the form of pharmaceutically acceptable metal salt, which is selected from lithium, calcium, magnesium, and zinc slats; and also to a method for preparing above-defined compounds and to pharmaceutical composition containing salts according to this invention. These compounds are used in treatment cardiac diseases or hypertension, in improvement of gastrointestinal blood circulation, and in treatment and prevention of cardiac disturbances induced by adriamicyn and analogous antitumor agents.

EFFECT: increased assortment of pharmaceutically active compounds of benzazepin series.

15 cl, 2 tbl, 5 ex

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RU 2 303 041 C2

Authors

Van Der Ehrden Joris A.

De Jong Paulus P. G.

Van Der Mej Paulus F. K.

Dates

2007-07-20—Published

2003-01-15—Filed