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2 164 223

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IPC

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Application

99110952/04, 1999-05-20

(24)

Start date

1999-05-20

(22)

Actual filing date

1999-05-20

(45)

Published

2001-03-20

(72)

Inventor

Beljakov N.G.Lomzakova V.I.Kosmynina G.V.

(73)

Holder

Gosudarstvennyj Nauchnyj Tsentr Rf

METHOD OF PREPARING 2-(3,4-DIOXYPHENYL)ETHYLAMINE HYDROCHLORIDE Russian patent published in 2001 - IPC

Abstract RU 2164223 C2

FIELD: medicine. SUBSTANCE: described is improved method of preparing 3-(3,4-dioxyphenyl) ethylamine hydrochloride which is medicinal dophamine agent which regulates functions of endocrine glands and transfers nerve pulses. Method comprises treating 2-(3,4-dioxyphenyl)ethylamine in free from or as hydrochloride with concentrated hydrochloric acid in inert gas at temperatures from 140 to 160 C, and recovery of the desired product is carried out by cooling the resulting reaction mixture to temperatures from 0 to 10 C and filtration in gas current. Method makes it possible to increase yield of the desired product from 42 to 96-97%, improved quality of the desired product (melting temperature rises from 242 to 245 C and content of main agent in the product is not lower than 98.5%). EFFECT: more efficient preparation method. 3 ex

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RU 2 164 223 C2

Authors

Beljakov N.G.

Lomzakova V.I.

Kosmynina G.V.

Dates

2001-03-20—Published

1999-05-20—Filed

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