METHOD OF PREPARING DIIODOMETHYLATE OF SUCCINIC ACID 2- DIMETHYLAMINOETHYL ESTER Russian patent published in 2000 - IPC

Abstract RU 2155745 C2

FIELD: organic chemistry, more particularly preparation of diiodomethylate of succinic acid 2-dimethylaminoethyl aster (dithiline). SUBSTANCE: dithiline is biologically active compound, namely muscle relaxant of depolarizing activity. Succinic anhydride is made to react with 2-dimethylaminoethanol in the presence of toluene at 130-145 C and succinic anhydride to 2- dimethylaminoethanol to toluene molar ratio of 1:(3.0- 3.5):(0.5-1.0) followed by guaternization with iodomethane in aqueous ethanolic or aqueous acetonic medium containing 80-30% of ethanol or acetonic. Said method makes it possible to prepare product which has high degree of purity and meets requirements of Russia's pharmacopoeia. EFFECT: improved properties of the title product. 6 ex

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RU 2 155 745 C2

Authors

Gudzenko V.I.

Shebelova I.V.

Pomogaeva L.S.

Kruglik A.E.

Dates

2000-09-10—Published

1998-12-03—Filed