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2 078 820

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C1

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IPC

(21) (22)

Application

94037988/13, 1994-09-30

(22)

Actual filing date

1994-09-30

(45)

Published

1997-05-10

(72)

Inventor

Romanova Ju.R.Lisovskaja K.V.Aleksandrova G.I.Rudenko L.G.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Ramn

STRAIN A/47/PEKING/92/3 (H3N2) FOR PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR CHILDREN Russian patent published in 1997 - IPC

Abstract RU 2078820 C1

FIELD: medicinal virology. SUBSTANCE: vaccine strain A/47/Peking/92/3 is a reassortant obtained by crossing epidemic virus A/Peking/32/92 (H3N2) with cold-adapted temperature-sensitive virus A/Leningrad/134/47/57 (H2N2) - attenuation donor that is harmless for adult and children. Strain is deposited in GISK at N 104. Strain A/47/Peking/92/3 multiplicates actively in developing chick embryos at optimal temperature 32-34 C. Reassortant strain inherited two genes encoding surface proteins (hemagglutinin and neuraminidase) from epidemic virus and six genes encoding nonglycolized proteins from attenuation donor. Strain A/47/Peking/92/3 (H3N2) is nonreactive for children of age 3-15 years at intranasal administration route. EFFECT: vaccine strain indicated above. 1 tbl

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RU 2 078 820 C1

Authors

Romanova Ju.R.

Lisovskaja K.V.

Aleksandrova G.I.

Rudenko L.G.

Dates

1997-05-10—Published

1994-09-30—Filed

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