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2 077 581

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C1

(51)

IPC

(21) (22)

Application

94037450/13, 1994-09-30

(22)

Actual filing date

1994-09-30

(45)

Published

1997-04-20

(72)

Inventor

Gushchina M.I.Aleksandrova G.I.Khajder A.A.Rudenko L.G.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Ramn

STRAIN A/47/TEXAS/91/2/6 (H1N1) FOR PRODUCTION OF LIVING INFLUENZA INTRANASAL VACCINE FOR CHILDREN Russian patent published in 1997 - IPC

Abstract RU 2077581 C1

FIELD: virology. SUBSTANCE: vaccine strain A/47/Texas/91/2/6 - reassortant obtained by crossing epidemic virus A/Texas/36/91 (H1N1) with cold-adopted temperature-sensitive virus A/Leningrad/134/47/57 (H2N2) - attenuation donor that is harmless for adult and children. Strain A/47/Texas/91/2/6 is actively multiplicated in developing chicken embryos at optimal temperature 32-34 C and shows temperature-sensitivity and cold-adaptivity. Reassortant inherited from epidemic virus two genes encoding surface proteins (hemagglutinin and neuraminidase) from epidemic virus and six genes encoding nonglycolized proteins from attenuation virus. Strain A/47/Texas/91/2/6 (H1N1) is nonreactive for children (age 3-15 years) at intranasal administration. Strain is deposited in the State Virus Collection at N 104. EFFECT: construction of the strain indicated above. 1 tbl

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RU 2 077 581 C1

Authors

Gushchina M.I.

Aleksandrova G.I.

Khajder A.A.

Rudenko L.G.

Dates

1997-04-20—Published

1994-09-30—Filed

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