PYRONE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, INTERMEDIATE COMPOUNDS FOR PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION HAVING ANTIVIRAL AND ANTIBACTERIAL ACTIVITY BASED THEREON, AND METHOD OF TREATING RETROVIRUS- INDUCED INFECTIONS AND DISEASES Russian patent published in 2000 - IPC

FIELD: medicine. SUBSTANCE: described are pyrone derivatives of general formula I: wherein X is group of formula: OR₄ wherein R₄ is hydrogen unbranched alkyl having 1-6 carbon atoms, branched or cyclic alkyl having 3-7 carbon atoms; y is oxygen, C(R₄)₂ or NR₄ wherein R₄ is as defined above; R₁ and R₂ are independently [CH₂]_n1-[W₁]_n2-[Ar]_n2-[CH₂]_n3-[W₂]_n4-R₅ wherein n₁-n₄ and R₅ are as defined above; in this case, if W₁ is heteroatom, then n₁ is integer of 1-4, or R₁ and R₂ together form 3-, 4-, 5-, 6- or 7-membered ring unsubstituted or substituted by at least one of above- indicated residues of R₅; R₃ is group of formula [W₃]-[CH₂]_n3-[W₄]_n4-[Ar]_n2-[CH₂]_n3-[W₂]_n4-R₅ wherein n₁, n₂, n₃, n₄ and n₅ are independent and are integers of 0-4.0-1.0-4, 0-1 and 0-2, respectively. W₁, W₂ and W₄ are independent and are oxygen, OCONR₅, S(O)_n5, CO, NR₅, C(R₅)₂; W₃ is selected from group consisting of oxygen, S(O)_n5, NR₅; R₅ is independently hydrogen or residue Ar and unbranched or branched alkyl having 1-6 carbon atoms unsubstituted or substituted by at least one residue selected from group consisting of CO₂R₄, CON(R₄)₂, OR₄, chlorine, bromine, fluorine, trifluoromethyl, radical Ar or two radicals R₅ together form unsubstituted ring having 3-7 carbon atoms, and Ar is independently phenyl, naphthyl, benzo(1,3)dioxol, imidazolyl, pyrimidinyl, thienyl, cycloalkyl having 3-6 carbon atoms unsubstituted or substituted by residues selected form group consisting of fluorine, chlorine, bromine, cyano, amino, trifluoromethyl, and radical of formula (CH₂)_n6R₄ and (CH₂)_n6OR₄, wherein n6 is independently integer of 0-3, an R₄ is as defined above, or pharmaceutically acceptable salts thereof. Compounds are active ingredient of pharmaceutical composition having antiviral and antimicrobial activity. Also described are intermediate compounds for preparing pyrone-derivatives of formula 1 and also method of treating retrovirus-induced infection or disease by introducing pyrone derivatives of formula I in therapeutically effective amount. EFFECT: improved properties of the title compounds. 21 cl, 113 ex, 4 tbl