FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to optically active derivatives of benzothiepine of the formula (I) 
where R means lower alkyl group; 
and R2 mean independently lower alkyl group or in common they mean lower alkylene. Compound of the formula (I) shows an excellent osteogenesis- -activating effect and useful as a prophylactic or therapeutic agent in bone diseases. Invention describes method of its synthesis, activators of osteogenesis, method of osteogenesis activation and methods of treatment of patients. EFFECT: inhibition of bone resorption, enhanced activation of bone formation. 15 cl, 1 tbl, 16 ex
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1996 |
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- Muranisi Khiroja
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| SULFUR-CONTAINING HETEROCYCLIC COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF |
1989 |
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1995 |
- Jasuo Sugijama
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| DERIVATIVES OF 4,1-BENZOXAZEPINE, PHARMACEUTICAL COMPOSITION, METHOD OF INHIBITION OF ACTIVITY OF SQUALENE SYNTHETASE IN MAMMALS, METHOD OF INHIBITION OF FUNGI GROWTH IN MAMMALS |
1993 |
- Khidefumi Jukimasa
- Rjuiti Tozava
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1990 |
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| FUSED HETEROCYCLIC COMPOUNDS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1991 |
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RU2095361C1 |
| DERIVATIVES OF 4,1-BENZOXAZEPINE |
1993 |
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RU2170732C2 |
| DERIVATIVE OF DI- AND TRIAZOLYLPROPANE, METHODS OF ITS SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1996 |
- Katsumi Itokh
- Kendzi Okonogi
- Akikhiro Tasaka
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| AZOLE COMPOUNDS, METHOD OF THEIR SYNTHESIS, ANTIFUNGAL PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT OF FUNGAL INFECTION |
1998 |
- Itokh Katsumi
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RU2189982C2 |
| DERIVATIVES OF AZOLE, METHODS OF THEIR SYNTHESIS AND ANTIFUNGAL AGENT |
1994 |
- Katsumi Iton
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- Akikhiro Tasaka
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