(-)-CIS-6(S)-PHENYL-5(R)-[4-(2-PYRROLIDINE-1-YLETHOXY)PHENYL]- -5,6,7,8-TETRAHYDRONAPHTHALINE-2-OL D-TARTRATE, METHOD OF ITS SYNTHESIS, METHOD OF PROPHYLAXIS OF STATES INFLUENCING WITH TO EFFECT OF ESTROGEN AGONISTS, PHARMACEUTICAL COMPOSITION Russian patent published in 2001 - IPC

Abstract RU 2162465 C2

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes method of synthesis of (-)-cis-6(S)-phenyl-5(R)- -[4-(2-pyrrolidine-1-ylethoxy)phenyl] -5,6,7,8-tetrahydro- -naphthaline-2-ol D-tartrate that is useful as estrogen agonist and can be used for prophylaxis of states in mammals that can be influenced with effect of estrogen agonists, for example, in the case of osteoporosis, cardio-vascular disease, hyperlipidemia prostate disease, hypercholesterolemia, obesity, breast cancer, endometriosis. EFFECT: valuable medicinal properties of compound, improved method of synthesis. 11 cl, 1 ex

Similar patents RU2162465C2

Title	Year	Author	Number
METHOD OF SYNTHESIS OF CIS-1-{2-[4-(6-METHOXY-2-PHENYL-1,2,3,4-TETRAHYDRONAPHTHALENE-1-YL)-PHENOXY]ETHYL}PYRROLIDINE AND INTERMEDIATE COMPOUNDS	2000	Chiu Charl'Z Kvok-Fung	RU2195445C2
COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT AND PROPHYLAXIS OF ENDOMETRITIS, INTERMEDIATE COMPOUND	1996	Kimberli O.Kameron Pol' A.Dasilva Zhardine Robert L.Rozati	RU2130454C1
PURIFIED LASOFOXIPHENE AND METHOD FOR PURIFYING RACEMIC LASOFOXIPHENE BY RECRYSTALLIZATION	2003	Maklaflin Robert Uill'Jam Sklavounos Konstantin Uotson Garri Ostin Ml.	RU2278861C2
PHARMACEUTICAL COMPOSITION AND SET FOR TREATMENT OF REDUCED OSSEOUS MASS (VERSIONS)	1996	Ke Khua Zu Tompson Dehvid D.	RU2190395C2
STIMULATING AGENTS OF GROWTH HORMONE SECRETION	1996	Filip A. Karpino Pol A. Dasil'Va Dzhardin Brjus A. Lefker Dzhon A. Rehgehn	RU2172742C2
METHOD OF PRODUCING DERIVATIVES OF 3-(2-HYDROXY-4-SUBSTITUTED BY PHENYL) CYCLOALKANOLE	0	Majkl Ross Dzhonson Lorens Sherman Melvin	SU1378780A3
RACEMIC AND OPTIC ACTIVE DERIVATIVES OF TETRALIN AND 7-HYDROXYTETRALIN	1992	Dzhejms Frederik Ehggler[Us] Ehntoni Marfet[Us] Lorens Sherman Melvin	RU2073673C1
NEW TETRACYCLIC COMPOUNDS CONTAINING HETEROATOM, USED AS SELECTIVE MODULATORS OF OESTROGEN RECEPTORS	2003	Kanodzhia Ramesh M. Dzhejn Nareshkumar F. Ng Rejmond Sui Zikhua Sjuj Tszjai	RU2331645C2
TETRACYCLIC HETEROCOMPOUNDS AS ESTROGEN RECEPTOR MODULATING AGENTS	2002	Kanodzhia Ramesh M. Dzhejn Nareshkumar F. Ng Rejmond Sui Zikhua Ksu Dzhiaji	RU2305099C2
METHOD FOR PRODUCTION OF SUBSTITUTED (3-BENZYLAMINO)-2-PHENYL PIPERIDINES, SUBSTITUTED (3-BENZYLAMINO)-2-PHENYL PYRIDINE AND METHOD FOR ITS PRODUCTION	1991	Denniz M.Godek[Us] Terri Dzh.Rouzen[Us]	RU2077531C1

RU 2 162 465 C2

Authors

Charl'Z K. Chiu

Morgan Mel'Tts

Dates

2001-01-27—Published

1996-10-04—Filed