PURIFIED LASOFOXIPHENE AND METHOD FOR PURIFYING RACEMIC LASOFOXIPHENE BY RECRYSTALLIZATION Russian patent published in 2006 - IPC C07D295/08 C07D207/04

Abstract RU 2278861 C2

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for purifying racemic cis-6-phenyl-5-[4-(2-pyrrolidine-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalene-2-ol that involves the following stages: (a) suspending racemic cis-6-phenyl-5-[4-(2-pyrrolidine-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalene-2-ol in ethanol and tetrahydrofuran mixture to form suspension wherein indicated mixture of ethanol and tetrahydrofuran has the volume ratio from 4:1 to 1:1; (b) stirring and heating the indicated suspension; (c) cooling the indicated suspension from the stage (b), and (d) collection of solid purified racemic cis-6-phenyl-5-[4-(2-pyrrolidine-1-ylethocy)phenyl]-5,6,7,8-tetrahydronaphthalene-2-ol. Method provides preparing the end product containing less 0.1% of impurities.

EFFECT: improved purifying method.

11 cl, 11 tbl, 11 ex

Similar patents RU2278861C2

Title	Year	Author	Number
(-)-CIS-6(S)-PHENYL-5(R)-[4-(2-PYRROLIDINE-1-YLETHOXY)PHENYL]- -5,6,7,8-TETRAHYDRONAPHTHALINE-2-OL D-TARTRATE, METHOD OF ITS SYNTHESIS, METHOD OF PROPHYLAXIS OF STATES INFLUENCING WITH TO EFFECT OF ESTROGEN AGONISTS, PHARMACEUTICAL COMPOSITION	1996	Charl'Z K. Chiu Morgan Mel'Tts	RU2162465C2
COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT AND PROPHYLAXIS OF ENDOMETRITIS, INTERMEDIATE COMPOUND	1996	Kimberli O.Kameron Pol' A.Dasilva Zhardine Robert L.Rozati	RU2130454C1
METHOD OF SYNTHESIS OF CIS-1-{2-[4-(6-METHOXY-2-PHENYL-1,2,3,4-TETRAHYDRONAPHTHALENE-1-YL)-PHENOXY]ETHYL}PYRROLIDINE AND INTERMEDIATE COMPOUNDS	2000	Chiu Charl'Z Kvok-Fung	RU2195445C2
STIMULATING AGENTS OF GROWTH HORMONE SECRETION	1996	Filip A. Karpino Pol A. Dasil'Va Dzhardin Brjus A. Lefker Dzhon A. Rehgehn	RU2172742C2
PHARMACEUTICAL COMPOSITION AND SET FOR TREATMENT OF REDUCED OSSEOUS MASS (VERSIONS)	1996	Ke Khua Zu Tompson Dehvid D.	RU2190395C2
8-SUBSTITUTED-2-AMINOTETRALINE DERIVATIVES AND METHODS OF PREPARATION THEREOF	1990	Nil'S-Ehrik Anden[Se] Berit Kristina Ehlizabet Baklund Khek[Se] Anna Lena Marija B'Erk[Se] Uli Al'F Khaksell[Se] Sven-Ehrik Khillver[Se] Ie Liu[Cn] Eva Sharlotta Mellin[Se] Eva Marie Persson[Se] Karl Erk Vallgarda[Se] Khong Iu[Cn]	RU2093507C1
PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF	2020	Bogdan, Endryu Khalvorsen, Dzheff T. Farni, Elliot P. Frost, Dzhennifer M. Kim, Filip R. Matulenko, Mark A. O`Konnor, Mettyu Shirudi, Reza Vojt, Erik Syun, Chzhaomin Chzhan, Tsinvej Baumgartner, Kristina Ebbott, Dzhejson Ikonomu, Kristos Fosu, Stejsi	RU2833220C2
NEW MORPHOLINOBENZAMIDE SALTS, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT	2000	Berg Stefan Son Daniel	RU2237668C2
SUBSTITUTED AMINOINDANS AND ANALOGUES THEREOF TO BE USED IN PHARMACEUTICS	2009	Rakel'Mann Nil'S Bjaly Loran Ehnglert Genrikh Virt Klaus Arndt Petra Uehston Dzhon Khajnel'T Uve Follmann Markus	RU2522586C2
METHOD FOR PREPARING BENZOPYRAN-2-OL DERIVATIVES	2007	Akhman Jens Bertil' Dillon Barri Richard Pettman Alan Dzhon	RU2397163C2

RU 2 278 861 C2

Authors

Maklaflin Robert Uill'Jam

Sklavounos Konstantin

Uotson Garri Ostin Ml.

Dates

2006-06-27—Published

2003-03-17—Filed