BENZOFURAN CARBOXAMIDES AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF Russian patent published in 2001 - IPC

FIELD: pharmaceutical chemistry. SUBSTANCE: invention provides novel benzofuran carboxamides depicted by general formula I: (I), in which Z is CO group; R₁ is alkoxy group optionally substituted by one or several halogen atoms; R₂ and R₃, identical or different, are hydrogen, groups R₆,OR₁₀,COR₆,C(=NOR₆)R₆, alkyl-C(=NOR₆)R₆, C(=NOR₆)R₆,NR₈R₉, CN, CF₃, COOH, and COOR₁₀; R₄ is hydrogen or alkyl; R₅ aryl, heteroaryl, and heterocyclic radical, alkyl/aryl/heteroaryl/heterocyclic moieties in R₄ and/or R₅ being optionally substituted by one or several substituents R₁₃; R₆ is group R₁₀ optionally substituted in any position by groups R₁₆; R₇ is hydrogen or alkyl; R₈ hydrogen, heteroarylalkyl, heterocycloalkyl, or alkoxycarbonyl; R₉ hydrogen, heteroarylalkyl, or alkyl; R₁₀ alkyl, cycloalkyl, aryl, heteroaryl, heterocyclic radical, arylalkyl, heteroarylalkyl, or heterocycloalkyl; R₁₁ hydrogen or alkyl; R₁₂ hydrogen; R₁₃ alkyl optionally substituted by hydrogen, alkoxy optionally substituted by halogen, heterocyclic radical, hydroxy, COOR₇, halogen, CN, or S(O)_nR₁₀; R₁₄ is hydroxyl, carbonyl oxygen, OR₁₀, NR₈R₉, CN, COOH, CO₂R₁₀, or CONR₁₁R₁₂; and n is equal to 0; or their pharmaceutically acceptable salts. Pharmaceutical composition is also described. Compounds I can be used as phosphodiesterase inhibitors and in treatment of pathologic conditions caused by proteins mediating cellular activity. EFFECT: extended assortment of biologically-active compounds. 20 cl, 2 tbl, 52 ex