QUINOLINE CARBOXAMIDES AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2001 - IPC

Abstract RU 2170730 C2

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel quinolines of the formula (I) where X means CO; R means H, halogen atom; R1 means H, lower alkoxy-group optionally substituted with halogen atoms; R2, R3, R4 mean H, R7, OR11, COR7, C(=NOR7)R7, CF3, lower alkyl-C(= NOH)R7, CN, NR9R10 or CON-R12R13 where N-R12R13 is six-membered heterocycle containing one or two N atoms as a heteroatom optionally substituted with one or more R15; R5 means H; R6 means phenyl, six-membered heterocycle containing one or two similar or different heteroatoms taken among nitrogen and oxygen atom substituted with R14; R7 means R11 optionally substituted with R16; R8 means alkyl; R9 means H, aklylcarbonyl, lower alkoxycarbonyl, heteroarylcarbonyl; R10 means H, lower alkyl; R11 means lower alkyl, C3-C7- cycloalkyl, six-membered heterocycle containing one or two nitrogen atoms as a heteroatom optionally substituted with R15, phenylalkyl; R12 and R13 mean H or NR12R13 where NR12R13 means six-membered heterocycle containing one or two N atoms as a heteroatom optionally substituted with R15; R14 means CO2R8, halogen atom, -CN, lower alkyl optionally substituted with halogen atom, lower alkoxy-group; R15 means lower alkyl; R16 means OR11, NR9R10, CO2H, CO2R11, or its pharmaceutically acceptable salt. Invention relates to also pharmaceutical composition containing compound of the formula (I) and eliciting inhibitory activity with respect to phosphodiesterase-IV and tumor necrosis factor. EFFECT: new compounds indicated above, valuable biochemical and medicinal properties. 26 cl, 64 ex

Similar patents RU2170730C2

Title Year Author Number
BICYCLIC CARBOXAMIDES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF 1997
  • Dajk Khehjzel Dzhoan
  • Montana Dzhon Gari
RU2176642C2
HETEROCYCLIC COMPOUND N-OXIDES SHOWING INHIBITORY ACTIVITY ON TNF AND PDE-IV 1999
  • Dajk Khejzel Dzhoan
  • Montana Dzhon Gari
RU2205830C2
BENZOFURAN CARBOXAMIDES AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF 1997
  • Dajk Khehjzel Dzhoan
  • Lou Kristofer
  • Montana Dzhon Gari
  • Kendall Khannakh Dzhehjn
  • Sabin Veriti Margaret
RU2162467C2
DERIVATIVES OF HYDROXAMIC AND CARBOXYLIC ACID SHOWING MMP-INHIBITING ACTIVITY AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF 1998
  • Bakster Ehndrju Duglas
  • Ouehn Dehvid Alan
  • Montana Dzhon Gari
  • Uotson Robert Dzhon
RU2210567C2
DERIVATIVES OF BENZANILIDE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION EXHIBITING ANTAGONISM TO 5-HT RECEPTORS 1992
  • Aleksander Vill'Jam Oksford[Gb]
  • Vill'Jam Leonard Mitchell[Gb]
  • Dzhon Brehdshou[Gb]
  • Dzhon Uotson Kliterou[Gb]
  • Mal'Kol'M Karter[Gb]
RU2077535C1
METHOD OF PRODUCING DERIVATIVES OF DICHLOROANILINE, OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, OR SOLVATES 0
  • Lorens Genri Charlz Lants
SU1590042A3
DERIVATIVES OF 3-(5-TETRAZOLYLBENZYL)-AMINOPIPERIDINE, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION ON SAID 1994
  • Armur Dankan Robert
  • Ehvans Brajan
  • Midlmiss Dejvid
  • Nehjlor Alan
  • Pegg Nil Ehntoni
  • Vajnejder Marija Viktorija
  • Giblin Dzherard Martin Pol
  • Khabbard Tanja
  • Khehnn Majkl Mentehjt
  • Ljuehll Zjao-King
  • Uotson Stiven Pol
RU2136675C1
SUBSTITUTED BENZOTHIENYLPIPERAZINES, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION 1996
  • Nikolas Dzh.Rib
  • Dzhon G.Jurchak
  • Abdul E.Mertlib
RU2157371C2
ASAINDOLES 2002
  • Koks Pol Dzhozef
  • Madzhid Takhir Nadim
  • Laj Dzhastin Jeun Kvaj
  • Morli Ehndrju
  • Amendola Shelli
  • Depre Stefani Daniel'
  • Ehdlin Kris
  • Gardner Charl'Z Dzh.
  • Kominos Dorotea
  • Pedgrift Brajan Lesli
  • Khalli Frehnk
  • Gillespi Timoti Alan
  • Ehdvardz Majkl
  • Klerk Fransua Frederik
  • Nemechek Konsep'Son
  • Uje Oliver
  • Damur Dominik
  • Bushar Ehrve
  • Bezar Daniel'
  • Karre Shantal'
RU2326880C2
HETEROCYCLIC NITROGEN-CONTAINING DERIVATIVES OF CARBOXYLIC ACID, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION 1993
  • Donal'D Sjukaranevskij
  • Dzhoel S.Behrrish
  • Ehdvard V.Patrillo
  • Dzheffri A.Robl
  • Denis I.Riono
RU2124503C1

RU 2 170 730 C2

Authors

Dajk Khehjzel Dzhoan

Montana Dzhon Gari

Lou Kristofer

Kendall Khannakh Dzhehjn

Sabin Veriti Margaret

Dates

2001-07-20Published

1997-05-20Filed