FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel quinolines of the formula (I) where X means CO; R means H, halogen atom; R1 means H, lower alkoxy-group optionally substituted with halogen atoms; R2, R3, R4 mean H, R7, OR11, COR7, C(=NOR7)R7, CF3, lower alkyl-C(= NOH)R7, CN, NR9R10 or CON-R12R13 where N-R12R13 is six-membered heterocycle containing one or two N atoms as a heteroatom optionally substituted with one or more R15; R5 means H; R6 means phenyl, six-membered heterocycle containing one or two similar or different heteroatoms taken among nitrogen and oxygen atom substituted with R14; R7 means R11 optionally substituted with R16; R8 means alkyl; R9 means H, aklylcarbonyl, lower alkoxycarbonyl, heteroarylcarbonyl; R10 means H, lower alkyl; R11 means lower alkyl, C3-C7- cycloalkyl, six-membered heterocycle containing one or two nitrogen atoms as a heteroatom optionally substituted with R15, phenylalkyl; R12 and R13 mean H or NR12R13 where NR12R13 means six-membered heterocycle containing one or two N atoms as a heteroatom optionally substituted with R15; R14 means CO2R8, halogen atom, -CN, lower alkyl optionally substituted with halogen atom, lower alkoxy-group; R15 means lower alkyl; R16 means OR11, NR9R10, CO2H, CO2R11, or its pharmaceutically acceptable salt. Invention relates to also pharmaceutical composition containing compound of the formula (I) and eliciting inhibitory activity with respect to phosphodiesterase-IV and tumor necrosis factor. EFFECT: new compounds indicated above, valuable biochemical and medicinal properties. 26 cl, 64 ex
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Authors
Dates
2001-07-20—Published
1997-05-20—Filed