DERIVATIVES OF HYDROXAMIC AND CARBOXYLIC ACID SHOWING MMP-INHIBITING ACTIVITY AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2003 - IPC

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention describes derivatives of hydroxamic and carboxylic acid with MMP-inhibiting activity represented by the formula (I) where m = 0-1; X means SO₂; Y means OH or NHOH; R¹ means optionally substituted C_1-6-alkyl or piperidinyl; R² means hydrogen atom or C_1-6-alkyl; or CR¹R² means optionally substituted cycloalkyl, piperidinyl or tetrahydropyranyl; each B is similar or different and means hydrogen atom, C_1-6-alkylnaphthyl, C_1-6- alkylphenyl, C_1-6-alkyl, cycloalkyl that is condensed optionally with benzene, C_1-6-alkylcycloalkyl, phenyl, furanyl, thiophenyl, pyrrolyl that are optionally condensed with benzene, C_1-6-alkylbenzofuranyl, C_1-6- alkylbenzothiophenyl, C_1-6-alkylindolyl where any of these groups is substituted optionally, or B-N-B is piperidinyl substituted with =NOR⁴; or when neither R¹ nor R² is not hydrogen atom then B-N-B means piperazinyl, piperidinyl, pyrrolidinyl optionally condensed with benzene and optionally substituted; R⁴ means hydrogen atom, C_1-6-alkyl, phenyl, C_1-6-alkylphenol, pyridyl, pyrazinyl optionally substituted, and its salts, solvates, hydrates, protected amino, carboxy or protected derivatives of hydroxamic acid and pharmaceutical composition eliciting MMP-inhibiting activity. Described compounds can be used for treatment of prevention of state associated with activity of matrix metalloproteinases. EFFECT: valuable medicinal and biochemical properties of compounds. 13 cl