DERIVATIVES OF ARABINOFURANOSYLCYTOSINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel derivatives of arabinofuranosylcytosine of the formula (I) (Ara-C) where R₁ and R₂ are taken independently from hydrogen atom and C₁₈- and C₂₀-saturated and monounsaturated acyl groups under condition that R₁ and R₂ both are not hydrogen atom; if R₁ means hydrogen atom then R₂ does not mean eicosenoyl (cis, trans) when R₁ means eicosenoyl (cis, trans), oleoyl, stearoyl, eicosanoyl; if R₁ means eladoyl then R₂ does not mean eicosenoyl (cis, trans), stearoyl, eicosanoyl; if R₁ means oleoyl then R₂ does not mean eicosenoyl (cis, trans), stearoyl; if R₁ means eicosanoyl then R₂ does not mean stearoyl; if R₁ means stearoyl then R₂ does not mean eicosanoyl, oleoyl. Invention describes the use of derivative of Ara-C of the formula (I) for preparing pharmaceutical preparation for treatment of patients with solid tumors and lymphomas. Invention describes also pharmaceutical composition for treatment of patients with solid tumors and lymphomas. EFFECT: new derivatives indicated above, valuable antitumor properties. 12 cl, 21 dwg, 3 ex