DERIVATIVES OF HEMCYTABINE Russian patent published in 2002 - IPC

FIELD: organic chemistry. SUBSTANCE: invention relates to derivatives of hemcytabine of the formula (I) where R₁, R₂, R₃ are taken independently among hydrogen atom and C₁₈- and C₂₀-unsaturated and monounsaturated acyl groups under condition that all R₁, R₂, R₃ can't mean hydrogen atom. Compounds show antitumor activity and can be components of pharmaceutical composition of the similar designation. Also, invention proposes method of synthesis of hemcytabine derivatives involving interaction of hemcytabine with derivatives of monounsaturated C₁₈- or C₂₀-fatty acid FaX where X means removal group and Fa is acyl residue of indicated acid. EFFECT: improved method of synthesis, valuable antitumor properties of compounds. 1 cl, 7 tbl, 4 ex