IONTOPHORETIC DELIVERY OF ANTIMIGRAINE PREPARATION Russian patent published in 2001 - IPC

FIELD: medicine. SUBSTANCE: invention relates to iontophoretic delivery to patient suffering with migraine the compound of the formula (I) . Invention relates to also a device for iontophoretic delivery of compound of the formula (I) and composition containing compound of the formula (I) that can be used in this device. Indicated compounds are benzopyranal- - alkylaminoalkyl-substituted guanidines of the formula (I) their pharmaceutically acceptable salts of acid addition and their stereochemically isomeric forms where R¹ means hydrogen atom or C_1-6-alkyl; R² means hydrogen atom, C_1-6-alkyl, C_3-6- -alkenyl or C_3-6-alkynyl; R³ means hydrogen atom or C_1-6-alkyl; or R² and R³ taken in common form bivalent radical of the formula -(CH₂)_m where m = 4 or 5; or R¹ and R² taken in common form bivalent radical of the formula -CH=CH- or the formula -(CH₂)_n where n = 2, 3 or 4; or R³ can mean a bond when R¹ and R² taken in common form bivalent radical of the formula -CH=CH-CH=; R⁴ and R⁵ each means independently hydrogen atom or C_1-6-alkyl; Alk¹ means bivalent C_1-3-alkanediyl radical; Alk² means bivalent C_2-15-alkanediyl radical; and R⁶ and R⁷ each means independently hydrogen, halogen atom, C_1-6-alkyl, C_3-6-alkenyl, C_3-6-alkynyl, hydroxy-group, C_1-6-alkyloxy-group or cyano-group. Proposed device ensures to accelerate pain relief without adverse effects that are characteristic for oral antimigraine agents. EFFECT: improved method of delivery, enhanced curative effect. 22 cl, 4 tbl, 4 ex