N-[4-(HETEROARYLMETHYL)PHENYL]-HETEROARYLAMINES Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention discloses compounds of the formula (I) where R¹, R², R³, Het and are characterized in the description and also their oxides, pharmaceutically acceptable addition salts and stereochemically isomeric forms. Invention describes also preparing a pharmaceutical composition showing an inhibitory activity with respect to metabolism of retinoic acid and comprising therapeutically effective amount of compound of the formula (I) and a pharmaceutically acceptable carrier. Invention describes also methods of synthesis of a compound of the formula (I). EFFECT: improved method of synthesis and preparing, valuable biochemical properties. 20 cl, 8 tbl