FIELD: organic chemistry. SUBSTANCE: described is new method of preparing 4-carboxyphenyl-amide malonic acid ethyl ester by reacting malonic ester and aminobenzene derivatives using heating in the presence of organic solvent. Aminobenzene derivative is 4-aminobenzoic acid and organic solvent. Aminobenzene derivatives is 4- aminobenzoic acid and organic solvent is excessive amount of malonic ester, and process is carried out by heating to 135-140 C at 4-aminobenzoic to malonic ester molar ratio of 1:2.5. Method is practicable, technologically simple and ecologically clean, makes it possible to prepare chemical compounds which are useful as medicinals. EFFECT: more efficient preparation method. 1 ex
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Authors
Dates
2001-05-27—Published
2000-07-04—Filed