FIELD: organic chemistry. SUBSTANCE: invention relates to the novel method of synthesis of norbenzomorphane of the general formula (I) given in the invention claim where R1 is hydroxyl or C1-C8-alkoxyl which is the central intermediate compound used for synthesis of pharmaceutically valuable benzomorphane derivatives, in part, (-)-(1R,5S, 2''R)-3'-hydroxy-2-(2-metho- -xypropyl)-5,9,9-trimethyl-6,7-benzomorphane or [(-)-(2R, 6S, 2'R)-3-(2-methoxypropyl)-6,11,11-trimethyl-1,2,3,4,5,6- hexahydro-2,6-methanobenzo-α-oxacine-9-ol] . EFFECT: improved method of synthesis. 5 cl, 1 ex
Title | Year | Author | Number |
---|---|---|---|
XANTHINE DERIVATIVES AND THEIR PHARMACOLOGICALLY TOLERANTABLE SALTS | 1993 |
|
RU2138500C1 |
DERIVATIVES OF PHENYLAMIDINE | 1996 |
|
RU2184726C2 |
PYRAZINE DERIVATIVES AND THEIR ACID-ADDITIVE SALTS | 1992 |
|
RU2124008C1 |
METHOD OF PREPARING PURE ENANTIOMERS OF TROPIC ACID ESTERS (+) OR (-) WITH AMINO ALCOHOLS | 1996 |
|
RU2162850C2 |
DERIVATIVES OF PIPECOLINIC ACID AND THEIR SALTS AND PHARMACEUTICAL COMPOSITION | 1993 |
|
RU2140911C1 |
NOZZLE AND INHALER AND METHOD OF NOZZLE FABRICATION | 2009 |
|
RU2495726C2 |
DERIVATIVES OF ARYLGLYCINEAMIDES AND PHARMACEUTICAL COMPOSITION CONTAINING THESE COMPOUNDS | 1996 |
|
RU2167866C2 |
0 |
|
SU421187A3 | |
DERIVATIVES OF BENZOYLGUANIDINE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1997 |
|
RU2181720C2 |
METHOD OF PREPARING 2-TETRAHYDROFURIL-6,7-BENZOMORPHANES OR SALTS THEREOF | 0 |
|
SU588916A3 |
Authors
Dates
2001-05-27—Published
1996-08-02—Filed