METHODS OF SYNTHESIS OF NORBENZOMORPHANE Russian patent published in 2001 - IPC

Abstract RU 2167868 C2

FIELD: organic chemistry. SUBSTANCE: invention relates to the novel method of synthesis of norbenzomorphane of the general formula (I) given in the invention claim where R1 is hydroxyl or C1-C8-alkoxyl which is the central intermediate compound used for synthesis of pharmaceutically valuable benzomorphane derivatives, in part, (-)-(1R,5S, 2''R)-3'-hydroxy-2-(2-metho- -xypropyl)-5,9,9-trimethyl-6,7-benzomorphane or [(-)-(2R, 6S, 2'R)-3-(2-methoxypropyl)-6,11,11-trimethyl-1,2,3,4,5,6- hexahydro-2,6-methanobenzo-α-oxacine-9-ol] . EFFECT: improved method of synthesis. 5 cl, 1 ex

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RU 2 167 868 C2

Authors

Mattias Grauehrt

Kherbert Merts

Khanfrid Baltes

Dates

2001-05-27Published

1996-08-02Filed