FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of benzoylguanidine of the general formula (I) 
where R1 means alkyl with 1-8 carbon atoms; A means the group given in the invention claim; B means (-CH2-)a or (-CO-)b where a = 0-8, preferably, 1, 2, 3 or 4; b = 0, 1 or 2, preferably, 1; R2 means unsubstituted or substituted alkyl 1-8 carbon atoms, unsubstituted phenyl, NR3R4 or preferably five- membered heterocycle given in the invention claim where U, V, W, X and Z can mean CH, NH, O or S; R3 and R4 mean alkyl with 1-8 carbon atoms. Invention expands arsenal of derivatives of benzoylguanidine showing high inhibitory activity with respect to Na+/H+-exchange. Also, invention discloses a method of synthesis of these compounds and a pharmaceutical composition based on novel derivatives of benzoylguanidine. EFFECT: new compounds indicated above, improved method of synthesis, valuable biochemical properties. 5 cl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF OXADIAZOLE | 1997 |
|
RU2182905C2 |
| DERIVATIVES OF PHENYLAMIDINE | 1996 |
|
RU2184726C2 |
| XANTHINE DERIVATIVES AND THEIR PHARMACOLOGICALLY TOLERANTABLE SALTS | 1993 |
|
RU2138500C1 |
| DERIVATIVES OF ARYLGLYCINEAMIDES AND PHARMACEUTICAL COMPOSITION CONTAINING THESE COMPOUNDS | 1996 |
|
RU2167866C2 |
| BENZOYL GUANIDINE DERIVATIVES AND SALTS THEREOF WITH ACIDS | 1994 |
|
RU2136659C1 |
| AMIDINE DERIVATIVES, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS AND SALTS, PHARMACEUTICAL COMPOSITION SHOWING ANTAGONISTIC EFFECT WITH RESPECT TO LEUKOTRIENE-B | 1993 |
|
RU2124002C1 |
| DERIVATIVES OF PHENYLAMINOIMIDAZOLINE OR PHENYLIMINOIMIDAZOLIDINE ELICITIN G WITH PROPERTY OF AGONIST OF α-ADRENOCEPTORS AND PHARMACEUTICAL COMPOSI TION BASED ON THEREOF | 1996 |
|
RU2230061C2 |
| METHODS OF SYNTHESIS OF NORBENZOMORPHANE | 1996 |
|
RU2167868C2 |
| ISOQUINOLINE DERIVATIVES AND THEIR SALTS | 1994 |
|
RU2136664C1 |
| PYRAZINE DERIVATIVES AND THEIR ACID-ADDITIVE SALTS | 1992 |
|
RU2124008C1 |
