FIELD: biochemistry, amino acids. SUBSTANCE: invention describes compounds of the formula (I) and their pharmaceutically acceptable salts where substituents have values indicated in the description. Invention describes also to method of synthesis of compound of the formula (I) and pharmaceutical composition containing effective amount of compound of the formula (I) as an active component and pharmaceutically acceptable carrier or vehicle. The end compounds act as biological inhibitors of NO-synthase and they are useful as hypotensive, antibacterial, immunosuppressive, antiatherosclerotic, vasotrophic, analgetic, antimigraine, ophthalmological or antidiabetic preparations. EFFECT: improved method of synthesis and preparing, valuable medicinal properties. 11 cl, 5 tbl
Title |
Year |
Author |
Number |
AMIDINE DERIVATIVE SALTS AND CYCLOOXYGENASE INHIBITOR, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF |
1996 |
- P'Er-Eht'En Shabrie De Ljasson'Er
- Kolett Broke
|
RU2167856C2 |
NEW HETEROARYLOXYETHYL AMINES, METHOD OF PREPARING THEREOF, PHARMACEUTICAL COMPOSITION COMPRISING SAID AMINES HAVING AFFINITY WITH 5HT RECEPTORS AND INTERMEDIATE COMPOUNDS |
1997 |
- Bigg Deni
- Gal'Sera Mari-Odil'
|
RU2176639C2 |
CAMPOTECIN COMPOUNDS, METHODS OF PREPARATION THEREOF, INTERMEDIATES, AND THERAPEUTIC COMPOSITIONS |
1996 |
- Denni Bigg
- Oliv'E Lavern'
- Fransesk Plja Rodas
- Zhak Pomm'E
- Zherar Julibarri
|
RU2164515C2 |
PYRIMIDOBENZIMIDAZOLE DERIVATIVES AND APPLICATION THEREOF AS AGONISTS OR ANTAGONISTS OF MELANOCORTIN RECEPTORS |
2005 |
- Puatu Lidi
- Sakjur Karol'
- Bro Valeri
- Ruber P'Er
- Pla Paskal'
|
RU2392279C2 |
DERIVATIVES OF PIPERAZINE, COMPOUNDS, PHARMACEUTICAL COMPOSITION |
1997 |
- Bigg Deni
- Sharb'E De Ljason'Er P'Er-Eht'En
- Ovehn Serzh
- Oge Mishel'
|
RU2179554C2 |
DUAL INHIBITORS OF NO-SYNTHASE AND CYCLOOXYGENASE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1992 |
- P'Er-Eht'Enn Shabrie De Lasson'Er[Fr]
- P'Er Brake[Fr]
- Kolett Broke[Fr]
- Serzh Oven[Fr]
|
RU2104999C1 |
NOVEL ANALOGS OF CAMPTOTHECIN, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF |
1997 |
- Bigg Deni
- Lavern' Oliv'E
- Plja Rodas Fransesk
- Pomm'E Zhak
- Julibarri Zherar
|
RU2194051C2 |
DERIVATIVES OF 2-(IMINOMETHYL)AMINOPHENYL, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE COMPOUNDS |
1998 |
- Shabrie De Ljasson'Er P'Er-Eht'En
- Ovehn Serzh
- Bigg Denni
- Oge Mishel'
|
RU2183211C2 |
PYRIDOTHIENODIAZEPINES, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE COMPOUNDS |
2000 |
- Liberator Ann-Mari
- Bigg Denni
|
RU2245883C2 |
DERIVATIVES OF IMIDAZO-PYRIDINE, WITH AFFINITY TO MELANOCORTIN RECEPTOR |
2004 |
- Puatu Lidi
- Bro Valeri
- Sakjur Karol'
- Ruber P'Er
- Pla Paskal'
|
RU2358974C2 |