FIELD: medicine.
SUBSTANCE: there are described peptide exendin-4 derivatives amine-modified at a C-terminus and having a N-terminus bound with GLP-1-receptors, and partially or completely contain a peptide amino acid sequence of exendin-4. There is disclosed an application of the peptide exendin-4 derivatives for preparing a diagnostic and therapeutic agent for diseases whereat the GLP-1-receptors expression matters, for determination of the density of insulin-producing tissue cells, for determination of the GLP-1-receptors expression or density.
EFFECT: invention can be used for preparing the diagnostic and therapeutic agent for benign and malignant diseases whereat the GLP-1-receptors expression matters.
25 cl
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