THIENOPYRIMIDINE COMPOUNDS, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION Russian patent published in 2000 - IPC

FIELD: pharmaceutical chemistry. SUBSTANCE: invention provides thienopyrimidine compounds with general formula I: (I), in which Q is phenyl that can be substituted by one or several substituents from the group including halogen, alkoxy, and alkylthio groups; R² is C1-C16-alkyl optionally substituted by one or two alkoxy groups; phenyl radical optionally specified by one or two substituents selected from radicals alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, halogen, hydroxy, and alkoxyalkoxy; benzyl; or C5-C6- cycloalkyl; R³ is amino group substituted by one or two substituents selected from benzyl optionally substituted by C1-C6-alkylthio group, and C1-C6-alkyl optionally substituted by pyridyl group; and R⁴ is phenyl radical substituted by C1-C6-alkoxy optionally substituted by C1- C6-acyl, C1-C6-alkenyl, or C3-C6-cycloalkyl; nitro group; alkylaminocarbonyl; N-C1-C6-alkyl-N-C1-C6-alkylaminocarbonyl; amino group; C1-C6-alkylamino group; C1-C6-acylamino group optionally substituted by 1-3 C1-C6-alkoxy or halogens; N-C1-C6-alkyl- N-C1-C6-acylamino group; benzoylamino group; C1-C6- alkylsulfonylamino group; formamido group; or C1-C6-alkenyl optionally substituted by C1-C6-alkoxycarbonyl or C1-C6-acyl; and salts of indicated compounds. Compounds of invention are effective as preventive or therapeutic agents in cases of some hormone-dependent diseases, for instance sexual hormone-dependent cancer. Compounds are also effective as agents controlling fecundation capacity in both sex species and as agents promoting fish spawning. EFFECT: expanded therapeutic possibilities. 11 cl, 8 tbl, 24 ex