FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel bicyclic derivatives of thiophene of the general formula (I) 
where values R1,R2,R3,R4,R5, n are given in p. 1 of the invention claim. Compounds show antagonistic effect with respect to gonadotropin-releasing hormone. Invention describes also method of their synthesis and composition based on said. EFFECT: new compounds indicated above, valuable pharmacological property. 18 cl, 98 ex
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