3.1] NONANE DERIVATIVES. FIELD: chemical industry. SUBSTANCE: described is new method of preparing 3-azabicyclo [3.3.1] nonane derivatives of general formula I: wherein X is H and F; Y is OH, Cl, Br, COOH, C6H5; n is 1-8; m is 1-2 using Mannich reaction, Original 3,5-dinitrophenol fluoroalkyl ethers are reduced with NaBH4 to 1- polyfluoroalkoxy-3,5-bis(acinitro) cyclohex-1-ene disodium salts of formula II: wherein X is H and F; n is 1-8. Said disodium salt is reacted with mixture of formaldehyde, and primary amine and reaction solution is then acidified with acetic acid to pH of 6. EFFECT: more efficient preparation method. 3 cl
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Authors
Dates
2001-09-27—Published
1999-12-17—Filed