FIELD: organic chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, namely to a cocrystal of 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-1,6-diazaspiro[3,4]octane-1-yl]-3-oxopropanenitrile with 3.5-dimethylpyrazole of the formula [3a], where m is any number from 0.4 to 0.5. The invention also relates to a method for the production of a compound of the formula [4] by using the compound of the formula [3a].
EFFECT: method for the production of a compound of the formula [4] of the known BTK inhibitor from a cocrystal of the formula [3a] is developed, differ in high purity of the target compound and possibility of scaling for industrial production.
6 cl, 5 dwg, 16 ex
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