CYCLOSPORIN COMPOSITION FOR ORAL ADMINISTRATION (VERSIONS) AND METHOD OF ATTAINMENT OF IMMUNOSUPPRESSION IN RECIPIENT BODY Russian patent published in 2001 - IPC

FIELD: medicine, pharmacy. SUBSTANCE: composition has cyclosporin, at least one alcohol solvent having 2-3 carbon atoms, at least one nonionic polyhydroxyalkylene surface-active substance and at least one polyglycol. Surface-active substance is taken among the group including polyhydroxyethylene alcohols and monoesters of saturated acids and ethoxylated polyols with 4-6 carbon atoms. Polyglycol has molecular mass 800-1000 Da. Content of alcohol solvent is preferably 5-75 vol.% of composition and that of surface-active substance is 5-80%. Composition can be placed into solid capsule. Variant of composition involves additionally physiologically acceptable solvent being the composition is free of water practically. Method of attainment of immunosuppression in recipient body involves oral administration to recipient of the claimed composition. Invention ensures to administrate drug in patient by oral route that is more easily for patient. Invention can be used in transplantation of organs. EFFECT: improved properties of composition, absence of adverse effects. 16 cl, 6 dwg, 1 tbl, 42 ex