IMIDES AS TNF-ALPHA INHIBITORS Russian patent published in 2001 - IPC

FIELD: pharmaceutical industry. SUBSTANCE: described are new compounds such as cyclic imides of general formula: wherein R₁ is divalent residue of 3,4-pyridine, pyrrolidine, imidazole, naphthalene, or linear or branched alkane having 3-6 carbon atoms, unsubstituted or substituted by phenyl or phenyl having substituents nitro, cyano, trifluoromethyl, carbethoxy, carbmethoxy, carbpropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkyl having 1-4 carbon atoms, alkoxy having 1-4 carbon atoms, or halo compounds I are useful as NTF-alpha inhibitors, in which valent bonds of said residue are at vicinal carbon atoms in ring, R₂ is -CO- and n is 1, 2 or 3. Described are pharmaceutical compositions having properties of inhibiting TNF-alpha. EFFECT: improved properties of the pharmaceutical compositions. 44 cl, 99 ex, 3 tbl