SUBSTITUTED AMIDES, METHOD OF DECREASE OF TNF LEVEL, METHOD OF INHIBITION OF TNF-ACTIVATED REPLICATION OF RETROVIRUSES AND PHARMACEUTICAL COMPOSITION Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes substituted amides of the formula (I) TNF_α where TNF_α means substituted phenyl; is alkyl, phenyl, pyridyl, heterocyclyl and others; R¹ is ethylene, vinylene, branched alkylene and others; R² means R³, -CX where X is O or S. Compounds of the formula (I) have capability to decrease the level of R⁴ and inhibit CH₂-activated replication of retroviruses and therefore they can be used for control of cachexia, endotoxic shock and replication of retroviruses. Compounds of the formula (I) are synthesized by interaction of substituted amine with corresponding anhydride, phthalimide or aldehyde. EFFECT: improved method of synthesis, valuable antiviral properties. 21 cl, 13 ex