IMIDES, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHODS OF INHIBITION OF ACTIVITY OF PHOSPHODIESTERASE, α, ФHO Russian patent published in 2001 - IPC

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention describes novel compounds of the general formula (I) ЯФ_кB where one of and R¹ = R² is X and other means lower alkoxy-group; R³ is monocycloalkyl, bicycloalkyl, benzocyclo-alkyl with a number of carbon atoms up to 10; X is -O-; R³ is CO, R⁶; Y is -COZ, lower alkyl; Z is CH₂-, -OH, NH₂ or -R⁹ where -OR⁹ is lower alkyl and n = 0, 1, 2 and 3. New amides are inhibitors of R⁹ and phosphodiesterase and can be used for control of cachexia, endotoxic shock, replication of retro-viruses, asthma and inflammatory states. Typical example of these compounds is 3-phthalimido-3-(3-cyclopentylhydroxy-4- -methoxyphenyl)-propionamide. Invention describes also pharmaceutical composition based on these compounds and methods of inhibition of activity phosphodiesterae, ФHO_α and ФHO_α. EFFECT: new compounds indicated above, improved method of inhibition. 8 cl, 1 tbl, 22 ex