FIELD: organic chemistry, virology, pharmacy. SUBSTANCE: invention describes novel compounds of the general formula (I): Y-C(=O)-NH-CH-TNF2-C(= O)-Z where 
means 3,4-disubstituted phenyl where each substitute is taken independently of the group consisting of nitro-, cyano-, trifluoromethyl-, carboethoxy-, carbomethoxy-, carbopropoxy-, acetyl-, carbamoyl-, acetoxy-, carboxy-, hydroxy-, amino-group, alkyl with 1-10 carbon atoms, alkoxy-group with 1-10 carbon atoms and halogen atom; Z means alkoxy-group with 1-10 carbon atoms, benzylhydroxy-, amino- or alkylamino-group with 1-10 carbon atoms; and Y means (i) unsubstituted phenyl or phenyl substituted with one or more substitutes each of that is taken independently each of other among the group consisting of nitro-, cyano-, trifluoromethyl-, carboethoxy-, carbomethoxy-, carbopropoxy-, acetyl-, carbamoyl-, acetoxy-, carboxy-, hydroxy-, amino-group, alkyl with 1-10 carbon atoms, alkoxy-group with 1-10 carbon atoms and halogen atom or (ii) naphthyl. Arylamides of the general formula (I) are inhibitors of tumor cells necrosis factor R2 and can be used for control of cachexia, endotoxic shock and replication of retroviruses. Invention describes also pharmaceutical composition and method of inhibition of α-activated replication of retrovirus. EFFECT: improved method of inhibition of retrovirus replication. 16 cl, 14 ex
