FIELD: biochemical methods. SUBSTANCE: invention provides new "affine ligand/matrix" conjugates containing ligand bound to matrix support optionally through spacer group between matrix and ligand and to preparation thereof and their application in purification of protein materials such as, for example, immunoglobulins, insulin, factor VII, or human growth factor or its analogs, derivatives and fragments, and their precursors. EFFECT: enabled manufacture of inexpensive and stable affine columns. 83 cl, 12 tbl, 182 ex
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