DERIVATIVES OF 2,1,3-BENZOTHIADIAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND MEDICINAL AGENT Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of 2,1,3-benzothiadiazole of the general formula (I) where R means the group of the formula (I') ; X means S; R¹ means H, OH, OA; A means alkyl with 1-6 carbon atoms where 1-7 hydrogen atoms can be substituted with F. Compounds show properties of endothelin receptor antagonists and therefore they can be used for treatment of patients with hypertension, cardiac insufficiency, coronary heart diseases, renal, cerebral and myocardial ischemia. EFFECT: improved method of synthesis, valuable medicinal properties of compounds. 6 cl, 1 tbl, 24 ex