ARYLALKYLPYRIDAZINONES, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION Russian patent published in 2000 - IPC

FIELD: organic synthesis. SUBSTANCE: invention provides arylalkylpyridazinones of general formula I: (I), in which R¹ and R², independently of each other, are hydrogen or A; R³ and R⁴, independently of each other, are groups OR¹⁰; R⁵ is phenyl substituted by radical R⁶; Q is C1-C6-alkylene; R⁶ is one of radicals NH₂, -NR⁸R⁹, -NO₂; R⁸ hydrogen; R⁹ C2-C8-alkanoyl optionally substituted by 1-6 fluorine atoms, group -COOA or SO₂A; A is C1-C6-alkyl; R¹⁰ group A or C3-C7-cycloalkyl, and also physiologically acceptable salts thereof. Compounds I, their physiologically acceptable salts, and compositions based on these compounds and their salts inhibit phosphodiesterase IV and can be used for treatment of inflammatory processes, allergy, asthma, and autoimmune conditions. EFFECT: increased resource of pharmaceutical preparations. 4 cl, 1 tbl, 7 ex