PEPTIDE AND PROTEIN AEROSOL PREPARATIONS Russian patent published in 2001 - IPC

FIELD: proteins, pharmacy. SUBSTANCE: invention proposes a pharmaceutical aerosol preparation containing hydrofluoroalkane propellent, pharmaceutically active polypeptide of molecular mass up to 40 kDa and surface-active substance. Polypeptide is dispersed in propellent. C₈- C₁₆-Aliphatic acid or its salt, bile acid salt, phospholipid or alkyl-saccharide can be used as surface-active substance. Surface-active substance enhances systemic absorption of polypeptide in lower respiratory tracts and it is taken in the ratio surface-active substance : polypeptide from 1:10 to 1:0.2. Polypeptide aerosol preparation is used for topical or systemic treatment of patients with diseases of respiratory tracts. EFFECT: high bioavailability of polypeptides, good reproducibility. 43 cl, 8 ex