DERIVATIVES OF 4-(1-PIPERAZINYL)-BENZOIC ACID, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION Russian patent published in 2002 - IPC

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to novel derivatives of 4-(1- piperazinyl)-benzoic acid of the formula (I) where Ar means mono-, di- or tricyclic aryl having from 6 to 14 carbon atoms and Ar can has from 1 to 3 substitutes taken among the group including (C₁-C₈)-alkyl, (C₁-C₈)-alkoxy-group, halogen atom, trifluoromethyl-group; R₁ is taken among the group including hydrogen atom, cycloalkyl containing from 3 to 8 carbon atoms, (C₆-C₁₄)-aryl, heteroaryl-(C₁-C₆)-alkyl being heteroaryl is taken among the group including furyl; R₂ and R₃ are hydrogen atoms, and their solvates and pharmaceutically acceptable salts. Compounds can be used for treatment of patients with diabetes mellitus being mainly its insulin- nondependent form since the proposed compounds show hypoglycaemic effect but devoid of toxicity in effective doses. Invention describes also a pharmaceutical composition based on the claimed compounds and method of their synthesis. EFFECT: new compounds indicated above, improved method of synthesis, valuable antidiabetic properties. 4 cl, 2 tbl