FIELD: medicine, veterinary science, oncology. SUBSTANCE: the method describes a novel compound 5-oxymethyl-5-[3- (2- chlorethyl)-3-nitrozoureido] -2-cyclohexyl-1.3- dioxane of formula I of antitumor activity. Compound I represents a highly active cytotoxic preparation of pronounced therapeutic effect upon all three strains of interwoven tumors investigated. Comparison for antitumor activity in both the suggested preparation and CCNU upon leukemic mice P-338 has demonstrated the superiority of the suggested compound. EFFECT: improved antitumor activity of biologically active compounds to be applied in treating tumors in mice and rats. 3 tbl, 4 ex
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Year |
Author |
Number |
| 2-[3-(2-CHLOROETHYL)-3-NITROSOUREIDO]-1,3-PROPANEDIOL SHOWING ANTITUMOR ACTIVITY |
1992 |
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- Shenberg N.N.
- Ivin B.A.
- Filov V.A.
|
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2018 |
- Stukov Aleksandr Nikolaevich
- Esikov Kirill Aleksandrovich
- Usmanova Liliya Maratovna
- Konkov Sergej Anatolevich
- Semiglazova Tatyana Yurevna
- Filatova Larisa Valentinovna
- Bespalov Vladimir Grigorevich
- Tochilnikov Grigorij Viktorovich
- Vasileva Olesya Aleksandrovna
- Kireeva Galina Sergeevna
- Semenov Aleksandr Leonidovich
- Senchik Konstantin Yurevich
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- Vershinina Sofiya Fatkhutdinovna
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- Majdin Mikhail Aleksandrovich
- Yurova Mariya Nikolaevna
- Egormin Petr Andreevich
- Plakhov Evgenij Aleksandrovich
- Anisimov Vladimir Nikolaevich
|
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2018 |
- Stukov Aleksandr Nikolaevich
- Semiglazova Tatyana Yurevna
- Filatova Larisa Valentinovna
- Latipova Dilorom Khamidovna
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|
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2020 |
- Stukov Aleksandr Nikolaevich
- Tkachenko Elena Viktorovna
- Semiglazova Tatyana Yurevna
- Filatova Larisa Valentinovna
- Latipova Dilorom Khamidovna
- Kharitonova Natalya Nikolaevna
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|
RU2733643C1 |
| APPLICATION OF COMPOUND 2-[3-(2-CHLOROETHYL)-3-NITROSOUREIDO]-1.3-PROPANEDIOL FOR TREATMENT OF EHRLICH CARCINOMA, SARCOMA 37, LIO-1 LYMPHOSARCOMA, MELANOMA B16, TRANSPLANTED INTO LOWER EYELID OF MICE IN EXPERIMENT |
2020 |
- Stukov Aleksandr Nikolaevich
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- Zmitrichenko Yuliya Gennadevna
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|
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2023 |
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- Zhilinskaya Nadezhda Tarasovna
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| METHOD FOR PREDICTING POSTOPERATIVE COMPLICATIONS TYPE IN PATIENTS SUFFERING FROM LARGE INTESTINE CANCER FROM ANTEOPERATIVE GASTRINEMIA |
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| METHOD FOR TREATING UTERINE NECK CARCINOMA OF IB2β-III STAGE |
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0 |
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| METHOD TO TREAT MALIGNANT TUMORS IN ANIMALS |
1998 |
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